THz imaging setup for detecting oral cancer at −20 °C and 20 °C. The setup is designed in reflection mode and the sealed chamber is utilized to control the temperature inside. The aluminum film in the chamber is used to reflect the reference signal. (SC: sealed chamber, S: specimen, AL: aluminum film, QP: quartz plate, GC: gas controller, TL: Ti:sapphire laser, BS: beam splitter, M: mirror, G: THz generator, THz: THz radiation, OM: oscillating mirror, D: THz detector, PA: preamplifier)