Figure 7.

Enhanced GABA_A sensitivity in D₂ MSNs following D₂R activation. A, Confocal images of D₂ MSN segments with GFP (green) and gephyrin (red) staining in nontreated (left) and quinpirole-treated (right) conditions. Scale bar, 5 μm. B, Summary plots of gephyrin puncta density (left) and puncta intensity (right) of identified GFP+ and GFP− dendrites (**p < 0.01; Mann–Whitney U test). C, D, Representative currents in response to direct Y-tube application of GABA, THIP (1 μm), and etomidate (5 μm) in nontreated (C) and treated (D) D₂ MSNs. E, Summary of direct drug effects in D₁ and D₂ MSNs in each experimental condition (n = 16–24 cells/group; Kruskal–Wallis test with Dunn's post test: *p < 0.05, **p < 0.01, ***p < 0.001 comparing the same cell type between conditions; ^#p < 0.05, ^##p < 0.01 comparing different cell types within conditions).