Figure 2.

ASI peptidergic signaling is essential for the TA inhibition of 5-HT-stimulated aversive responses. A–D, Wild-type or mutant animals expressing the designated transgenes or RNAis were assayed for aversive responses to 30% 1-octanol with 5-HT ± TA. Black bars, Wild-type or null animals; gray bars, wild-type or null animals expressing a transgene; red bars, RNAi in wild-type animals, with promoters indicated. Data are presented as mean ± SE and analyzed by two-tailed Student's t test. *p < 0.001, significantly different from wild-type animals under identical conditions.