Table 2.

Cognitive Function, Clinical Psychopathology, and Extrapyramidal Symptoms in Reduction and Maintenance Groups^a

	Reduction Group (n = 31)				Maintenance Group (n = 30)				Difference in Change Between Groupsb
	Baseline		Change		Baseline		Change
	Mean	SD	Mean	SD	Mean	SD	Mean	SD	t	P
Cognitive function (RBANS)
Total scale	83.0	14.1	7.0	7.1	78.2	13.2	−0.1	8.0	3.67	<.001*
Immediate memory	71.5	16.7	11.0	12.2	70.0	16.0	5.3	9.3	2.04	.046*
Visuospatial/constructional	105	15.7	1.9	13.7	97.3	18.2	−2.4	12.5	1.28	.205
Language	91.9	15.5	3.7	10.3	90.4	11.5	−4.1	9.6	3.04	.004*
Attention	84.5	17.3	6.0	12.1	81.6	12.4	1.2	11.1	1.61	.112
Delayed memory	82.2	16.0	5.1	13.4	76.1	20.1	−0.4	16.4	1.44	.156
Clinical psychopathology
PANSS
Total	56.4	15.1	−6.7	10.3	56.3	11.7	−5.7	6.9	−0.43	.666
Positive	10.7	3.3	−1.0	2.0	10.4	3.3	−1.4	2.8	0.59	.559
Negative	16.8	6.2	−3.0	3.7	17.3	6.3	−1.3	2.8	−2.01	.049*
General psychopathology	28.9	7.3	−2.7	6.2	28.7	5.6	−3.1	4.6	0.25	.801
CGI-S	2.8	1.1	−0.2	0.7	2.8	0.9	0.0	0.6	−1.34	.186
CDSS total	3.1	2.7	−0.9	2.7	2.8	2.0	−0.5	1.8	−0.69	.492
Extrapyramidal symptoms (DIEPSS)
Total	3.1	3.3	−0.9	1.7	2.9	2.6	0.1	1.2	−2.64	.010*

Note: RBANS; Repeatable Battery for the Assessment of Neuropsychological Status, PANSS; Positive and Negative Syndrome Scale, CGI-S; Clinical Global Impression–Severity scale, CDSS; Calgary Depression Scale for Schizophrenia, DIEPSS; Drug-Induced Extrapyramidal Symptoms Scale.

^aLast observation carried forward (LOCF) method data.

^bNo significant differences in all baseline values between the 2 groups by Student’s t test.

*P < .05.