Table 3.
Relative risks and 95% confidence intervals for peripheral artery disease according to level of Lp(a).
|
WOMEN
| ||||
|---|---|---|---|---|
| Per 1 SD increase (28.8) |
Tertile | |||
| 1 | 2 | 3 | ||
| Range (mg/dL) | 0.1-8.4 | 8.5-35.0 | 35.1-144.6 | |
| No. Cases | 144 | 35 | 37 | 72 |
| Model 1 | 1.57 (1.33-1.86) | 1.0 (ref) | 1.04 (0.62-1.75) | 2.64 (1.64-4.26) |
| Model 2 | 1.54 (1.28-1.85) | 1.0 (ref) | 1.11 (0.64-1.94) | 2.76 (1.64-4.67) |
| Model 3 | 1.52 (1.24-1.87) | 1.0 (ref) | 1.37 (0.72-2.59) | 2.91 (1.58-5.36) |
|
| ||||
| MEN | ||||
|
| ||||
| Per 1 SD increase (22.8) |
Tertile | |||
| 1 | 2 | 3 | ||
| Range (mg/dL) | 0.1-2.4 | 2.5-12.0 | 12.1-129.1 | |
| No. Cases | 143 | 31 | 52 | 60 |
| Model 1 | 1.29 (1.09-1.52) | 1.0 (ref) | 1.88 (1.13-3.13) | 2.51 (1.49-4.21) |
| Model 2 | 1.27 (1.05-1.53) | 1.0 (ref) | 1.27 (0.73-2.22) | 1.91 (1.08-3.39) |
| Model 3 | 1.24 (1.00-1.53) | 1.0 (ref) | 1.20 (0.64-2.25) | 1.59 (0.84-3.00) |
|
| ||||
| POOLED | ||||
|
| ||||
| Model 3 | 1.36 (1.18-1.57) | 1.0 (ref) | 1.28 (0.82-2.00) | 2.18 (1.40-3.39) |
Model 1: adjusted for matching factors (age, race (women only), month of blood draw, fasting status, and smoking).
Model 2: adjusted for matching factors, triglycerides, HDL-C, LDL-C, hsCRP, and HbA1c.
Model 3: adjusted for matching factors, triglycerides, HDL-C, LDL-C, hsCRP, HbA1c, parental history of MI before age 60, pack-years of smoking, physical activity, hypertension, diabetes, hypercholesterolemia, BMI, aspirin use and postmenopausal hormone use (women only).