Table 4.
Relative risks and 95% confidence intervals for peripheral artery disease according to level of AA to MDA-LDL.
| IgG AA | IgM AA | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| WOMEN | |||||||||
|
| |||||||||
| Per 1 SD increase |
Tertile | Per 1 SD increase |
Tertile | ||||||
| log(IgG AA) | 1 | 2 | 3 | 1 | 2 | 3 | |||
| Range (RLU) | 1,465-6,580 | 6,581-11,017 | 11,018-57,009 | Range (RLU) | 2,013-15,741 | 15,742-22,494 | 22,495-77,968 | ||
| No. Cases | 144 | 40 | 56 | 48 | No. Cases | 144 | 50 | 34 | 60 |
| Model 1 | 1.16 (0.96-1.40) | 1.0 (ref) | 1.53 (0.95-2.45) | 1.26 (0.78-2.02) | Model 1 | 1.13 (0.95-1.36) | 1.0 (ref) | 0.59 (0.35-0.98) | 1.34 (0.84-2.13) |
| Model 2 | 1.16 (0.95-1.42) | 1.0 (ref) | 1.48 (0.89-2.46) | 1.32 (0.80-2.17) | Model 2 | 1.10 (0.91-1.34) | 1.0 (ref) | 0.57 (0.34-0.97) | 1.32 (0.81-2.17) |
| Model 3 | 1.10 (0.88-1.37) | 1.0 (ref) | 1.42 (0.79-2.53) | 1.13 (0.65-1.96) | Model 3 | 1.00 (0.80-1.26) | 1.0 (ref) | 0.47 (0.26-0.85) | 1.05 (0.60-1.85) |
|
| |||||||||
| MEN | |||||||||
|
| |||||||||
| Per 1 SD increase |
Tertile | Per 1 SD increase |
Tertile | ||||||
| log(IgG AA) | 1 | 2 | 3 | 1 | 2 | 3 | |||
| Range (RLU) | 485-1,940 | 1,941-3,690 | 3,691-64,956 | Range (RLU) | 732-7,203 | 7,204-11,833 | 11,834-94,623 | ||
| No. Cases | 143 | 57 | 40 | 46 | No. Cases | 143 | 45 | 44 | 54 |
| Model 1 | 0.94 (0.79-1.12) | 1.0 (ref) | 0.57 (0.35-0.93) | 0.73 (0.46-1.15) | Model 1 | 1.13 (0.96-1.34) | 1.0 (ref) | 0.91 (0.56-1.49) | 1.25 (0.80-1.97) |
| Model 2 | 0.87 (0.71-1.06) | 1.0 (ref) | 0.52 (0.30-0.89) | 0.54 (0.32-0.92) | Model 2 | 1.18 (0.97-1.43) | 1.0 (ref) | 0.83 (0.48-1.43) | 1.17 (0.70-1.96) |
| Model 3 | 0.84 (0.67-1.06) | 1.0 (ref) | 0.58 (0.31-1.08) | 0.52 (0.29-0.95) | Model 3 | 1.13 (0.93-1.39) | 1.0 (ref) | 1.02 (0.55-1.87) | 1.26 (0.71-2.23) |
Model 1: adjusted for matching factors (age, race (women only), month of blood draw, fasting status, and smoking status).
Model 2: adjusted for matching factors, triglycerides, HDL-C, LDL-C, hsCRP, and HbA1c.
Model 3: adjusted for matching factors, triglycerides, HDL-C, LDL-C, hsCRP, HbA1c, parental history of MI before age 60, pack-years of smoking, physical activity, hypertension, diabetes, hypercholesterolemia, BMI, aspirin use and postmenopausal hormone use (women only).