Table 3.
DVR-1 and dopamine occupancy (DA OCC) induced by d-amphetamine in monkey caudate and putamen measured using [11C]SV-III-130.
| Monkeya | Caudate DVR-1 | Putamen DVR-1 | ||||
|---|---|---|---|---|---|---|
| Baselineb | AMPHc | DAd OCC | Baselineb | AMPHc | DAd OCC | |
| Monkey 1 | 1.55 | 1.17 | 25% | 1.70 | 1.45 | 15% |
| Monkey 2 | 1.80 | 1.05 | 42% | 2.00 | 1.73 | 13% |
| Monkey 3 | 1.69 | 1.03 | 39% | 1.85 | 1.22 | 34% |
| Monkey 4 | 1.71 | 1.43 | 16% | 1.89 | 1.76 | 7% |
a
Four rhesus male monkeys were studied separately;
b
Baseline DVR-1 values represent test-retest average of at least two studies for each individual monkey;
c
D-amphetamine (AMPH) (1 mg/kg/i.v.) significantly decreased [11C]SV-III-130 binding potential in striatal regions: caudate (p = 0.001) and putamen (p = 0.03);
d
Percent dopamine (DA) occupancy (OCC) is higher in the caudate than in the putamen for all 4 monkeys.