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. 2007 May;83(3):77–96. doi: 10.2183/pjab.83.77

Fig. 12.

Fig. 12.

The metabolism of branched chain amino acids, and the synthesis of fatty acids and cholesterol.

Isovaleryl-CoA derived from leucine is catalyzed initially by isovaleryl-CoA dehydrogenase (IVD). 2-methylbutyryl-CoA and isobutyryl-CoA derived from isoleucine and valine, respectively, are both catalyzed initially by short/branched chain acyl-CoA dehydrogenase (SBCAD).