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. Author manuscript; available in PMC: 2014 Mar 1.
Published in final edited form as: Nat Neurosci. 2013 Aug 11;16(9):1299–1305. doi: 10.1038/nn.3486

Figure 1. Increased eIF2α phosphorylation in Alzheimer’s disease.

Figure 1

(a) eIF2α phosphorylation was increased in the hippocampus of APP/PS1 AD model mice. n=7 for both groups. p=0.041.(b) eIF2α phosphorylation was not altered in cerebellum of APP/PS1 AD model mice. n=11 for WT and n=10 for APP/PS1. p=0.080. (c) eIF2α phosphorylation was elevated in postmortem human AD brain samples. n=4 for AD and age-matched control groups. p=0.012. (d) DAB staining revealed increased eIF2α phosphorylation in the hippocampus of postmortem human AD brains, representative of three independent experiments. Scale bar, 150 μm. (e) ATF4 levels were increased in the hippocampus of APP/PS1 mice compared to WT littermates. n=6 for each group. p=0.044 Full-length blots/gels are presented in Supplementary Figure 7.