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General procedure for the synthesis of 6-substituted benzoxazole derivatives.
Reagents and conditions: (a) RCHO, O2, DarcoKB, xylene, 120 °C, 6 h, 75% (b) H2 (1 atm), 10% Pd-C, EtOAc, rt, 6 h, 85% (c) (S)-2,3-di-Cl-PhOCH(CH3)COOH, EDCI•HCl, DMF, 0 °C - rt, 12 h, 76%.
