Skip to main content
. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: J Med Chem. 2013 May 13;56(10):4028–4043. doi: 10.1021/jm400241j

Table 5.

SAR of benzyl amide derivatives of 1 for CpIMPDH inhibition.

graphic file with name nihms479334u4.jpg
ID X R1 IC50 (nM)
(-) BSA (+) BSA
69 Me CH2Ph > 5000 n.d.
70 Me Ph 120 ± 20 130 ± 30
71 (S)-Me Ph >5000* n.d.
72 (R)-Me Ph 22.3 ± 5.9 28.0 ± 3.5
22 (R)-Me 2,3-di-ClPh 60 ± 3