Table 6.
SAR of secondary amine derivatives of 1 for CpIMPDH inhibition.
| ||||
|---|---|---|---|---|
| ID | X | R1 | IC50 (nM)
|
|
| (−) BSA | (+) BSA | |||
| 73 | Me | 2,3-di-ClPh | 2 ± 1 | 1.8 ± 0.5 |
| 15a | (S)- Me | 2,3-di-ClPh | 0.5 ± 0.1 | 1.1 ± 0.1 |
| 15b | (S)- Me | 1-naphthyl | 14 ± 6 | 15 ± 3 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.