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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: J Med Chem. 2013 May 13;56(10):4028–4043. doi: 10.1021/jm400241j

Table 7.

Mechanism of inhibition of CpIMPDH by selected compounds.

Cmpd Substrate Mechanism Kis (nM)
1 IMP NC 58 ± 5
NAD C 33 ± 8
63a IMP NC 1.6 ± 0.7
NAD C 0.9 ± 0.3
68 IMP NC 210 ± 10
NAD C 150 ± 30
72 IMP NC 100 ± 20
NAD C 40 ± 10
a

Q26 was analyzed using tight binding treatment;

NC: noncompetitive; C: competitive.