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. Author manuscript; available in PMC: 2013 Nov 10.
Published in final edited form as: Nature. 2013 May 1;497(7448):211–216. doi: 10.1038/nature12143

Figure 2. Aging manipulations by hypothalamic IKKβ/NF-κB.

Figure 2

MBH-IKKβ, MBH-IκBα and MBH-Con mice were generated using ~18-month-old C57BL/6 mice (chow-fed males). a. Dual synapsin (Syn) promoter-directed lentiviral vectors. b. Lifespan of these mice (n = 23 – 31 mice per group). c&d. Mice at ~6 months post gene delivery were assessed for cognition via T-maze (c) and muscle endurance (d). e–h: Mice were scarified at 8~10 months post gene delivery for measuring muscle (quadriceps) fiber size (e), dermal thickness (f), bone mass (g), and tail tendon breaking time (h). *P < 0.05, **P < 0.01; MBH-Con: n = 23 (b), 9 (c), 6 (d), 3 (e&f), 4 (g), and 7 (h); MBH-IKKβ: n = 24 (b), 10 (c), 6 (d), 3 (e&f), 4 (g), and 5 (h); MBH-IκBα: n = 31 (b), 12 (c), 7 (d), 3 (e&f), 6 (g), and 8 (h). Error bars reflect mean ± SEM.