Table 2. Independent antecedents of fractional anisotropy and mean diffusivity regional abnormalities from the EPI cohort identified in multiple regression analyses.
| Mean FA Difference (95% CI) | Mean MD Difference (95% CI) | |
| Antenatal | ||
| Maternal hypertension | PLIC −0.042 (−0.067, −0.017)** | FPVZ 0.060 (−0.011, 0.131) |
| Private medical insurance | OPVZ 0.012 (−0.001, 0.025) | FPVZ −0.073 (−0.142, −0.005)* |
| Outborn status | PLIC 0.056 (0.003, 0.108)* | |
| Antenatal steroids | SVZ −0.129 (−0.240, −0.018)* | |
| Chorioamnionitis | CC 0.053 (0.008. 0.098)* | |
| Intrapartum | ||
| Rupture of membranes (hours) | PLIC −0.0001 (−0.0002, −0.00001) | OPVZ 0.0003 (−0.00004, 0.001) |
| Hypothermia | OPVZ 0.101 (−0.014, 0.216) | |
| Postnatal | ||
| Birth weight (grams) | CC 0.0001 (−0.00001, 0.0002) | PLIC −0.0001 (−0.0002, −0.00003)** |
| Caucasian | FPVZ −0.044 (−0.085, −0.003)* CS −0.047 (−0.087, −0.006)* | |
| Female sex | CS −0.060 (−0.127, 0.008) | |
| White matter injury on cranial ultrasound | PLIC −0.041 (−0.075, −0.008)* CC −0.057 (−0.103, −0.011)* | PLIC 0.047 (0.003, 0.092)* SVZ 0.214 (0.046, 0.383)* MCP 0.0001 (0.00004, 0.0002)** |
| Necrotizing enterocolitis | OPVZ −0.041 (−0.075, −.007)* | OPVZ 0.313 (0.045, 0.580)* CC 0.145 (0.024, 0.266)* |
| Patent ductus arteriosus | CC −0.031 (−0.065, 0.003) | CC 0.069 (0.022, 0.116)** |
| Duration of human milk use (per 10 days) | CC 0.037 (0.019, 0.056)† | CC −0.026 (−0.055, 0.003) |
| Duration of caffeine therapy (per 10 days) | CC −0.012 (−0.023, −0.001)* | |
| Duration of mechanical ventilation prior to 36 weeks PMA (per 10 days) | OPVZ 0.027 (0.001, 0.052)* CS 0.029 (0.012, 0.046)** |
*
P<0.05,
**
P<0.01,
†
P<0.001.
(PLIC: posterior limb of internal capsule; FPVZ: frontal periventricular zone; OPVZ: occipital periventricular zone; CC: splenium and genu of corpus callosum; CS: centrum. semiovale; SVZ: subventricular zone; EC: external capsule; MCP: middle cerebellar peduncles).ALIC – anterior limb of internal capsule; PLIC – posterior limb of internal capsule; FPVZ – frontal periventricular zone; OPVZ – occipital periventricular zone; CC – corpus callosum; CS – centrum semiovale; SVZ – subventricular zone; EC – external capsule; MCP – middle cerebellar peduncles.