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. 2013 Aug 29;8(8):e72088. doi: 10.1371/journal.pone.0072088

Figure 4. The Age-specific High-risk HPV (hrHPV) Prevalence in the Steady-state Before and After Vaccination.

Figure 4

Unless otherwise stated, the results pertain to females under the base-case scenario. (a) The model prediction on the current hrHPV prevalence (upper curve) with the observed data (asterisks). The lower curves show the prevalence for three different single hrHPV types with low, moderate and fast clearance of infection (see Materials and Methods); (b) the prevalence of hrHPV and persistent hrHPV before and after vaccination; (c) hrHPV prevalence at different times since the onset of the vaccination program; (d) hrHPV prevalence in females and males, before and after vaccination; (e) HPV16 prevalence under different vaccine scenarios, waning vaccine protection induces a second peak in the prevalence curve; (f) model fits to hrHPV data under different waning rates of natural immunity (base-case, SIR, 0.2 1/year waning rate) and the corresponding post-vaccination prevalences.