Figure 2. SM934 treatment suppressed MOG-specific pro-inflammatory cytokines and enhanced MOG-specific anti-inflammatory cytokines production in splenocytes from EAE mice.

Splenocytes from immunized mice treated with vehicle or SM934 (10 mice per group) were isolated at the peak of disease (day 18 p.i.), re-stimulated with MOG_35–55 (10 µg/ml) for 72 hours. Culture supernatants were collected and indicated cytokine levels were measured by ELISA. Results were expressed as mean ± SEM. *, p<0.05 compared with vehicle control. Three independent experiments were performed with similar results.