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. 2013 Aug 29;8(8):e72735. doi: 10.1371/journal.pone.0072735

Figure 3. H. pylori CagL-Y58/E59 mediated stronger downstream signaling of FAK, EGFR and AKT than CagL-Y58D/E59K did.

Figure 3

The AGS cells were co-cultivated with CagL-Y58/E59 or CagL-Y58D/E59K H. pylori at pH 7.4 or pH 5.4 to check the expression ratios of (A) phospho-FAK & FAK, (B) phospho-EGFR & EGFR, and (C) phospho-AKT & AKT. There were significant differences in phosphorylation level of FAK, AKT at pH 5.4 and EGFR at pH 5.4 and 7.4 triggered between CagL-Y58/E59 or CagL-Y58D/E59K H. pylori (*p<0.05). The data were mean ± standard deviations. Each experiment was repeated in triplicate.