Table 1. The demographic characteristics, pepsinogen I/II ratio, and integrin α5β1 expressions among the different clinical groups with H. pylori infection.

Groups	Duodenal ulcer(n = 36)	Gastritis(n = 52)	Intestinal metaplasia(n = 46)	Gastric cancers(n = 38)	P
Mean age (yr)	52.9	58.5	54.5	62.9	0.01a, b
Female: Male	13: 23	23: 30	20: 26	16: 22	0.88d
Mean PG I/II ratio	9.12	11.02	8.90	8.50	0.097a, c
PG I/II <6.0%(n)	8.3 (3/36)	19.2 (10/52)	19.6 (9/46)	39.5 (15/38)	0.01d, e
Supranuclear or apical expression of integrin α5β1
Antrum	22.2 (8/36)	34.6 (18/52)	56.5 (26/46)	63.2 (24/38)	0.001d, e
Corpus	16.7 (6/36)	28.8 (15/52)	34.8 (16/46)	50.0 (19/38)	0.02d, e
The modified intensity of integrin α5β1 (median, [25th ∼75th IQR])
Antrum	2.0 [2.0 ∼2.0]	2.0 [1.0 ∼4.0]	4.0 [2.0 ∼4.0]	3.0 [2.0 ∼4.0]	0.05f, g
Corpus	2.0 [2.0 ∼2.0]	2.0 [1.0 ∼4.0]	2.0 [2.0 ∼4.0]	2.5 [2.0 ∼4.0]	0.353f

^aOne way ANOVA and post hoc comparisons by the least significant difference test.

^bDuodenal ulcer vs. Gastritis group, p = 0.048; Duodenal ulcer vs. Gastric cancer group, p = 0.001; Intestinal metaplasia vs. Gastric cancer group, p = 0.004.

^cGastritis vs. Intestinal metaplasia group, p = 0.05; Gastritis vs. Gastric cancer group, p = 0.027.

^dChi-square test;

^eLinear-by-linear association, PG I/II ratio<6.0, p = 0.004; supranuclear or apical expression, p<0.001 in antrum and p = 0.003 in corpus.

^fKruskal-Wallis one-way ANOVA by ranks and post hoc comparisons by Mann-Whitney U test.

^gDuodenal ulcer vs. Intestinal metaplasia group, p = 0.036; Gastritis vs. Intestinal metaplasia group, p = 0.017. PG I/II: indicates the ratio of pepsinogen I/pepsinogen II.