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. 2013 Aug 29;8(8):e72630. doi: 10.1371/journal.pone.0072630

Table 4. Factors associated with HIV drug resistance among the ART-failure individuals.

Factors Resistance% (N) Crude ORb (95% CI) P-value Adjusted OR(95% CI) P-value
Total 45.1 (232)
Gender
Male 43.2 (136) 1.00 0.27
Female 48.0 (96) 1.2 (0.9, 1.8)
Ethnics
Han 42.2 (167) 1.00 0.01 1.0 0.04
Others 54.6 (65) 1.7 (1.2, 2.6) 1.6 (1.0, 2.5)
Age (years) 0.36
<18 60.7 (17) 1.00
18–44 45.0 (174) 0.5 (0.2, 1.2)
≥45 44.2 (41) 0.5 (0.2, 1.2)
Transmission route
Sexual contact 47.1 (123) 1.0 0.02 1.0 <0.01
Drug injection 38.9 (77) 0.7 (0.5, 1.1) 0.6 (0.4, 0.9)
Transfusion or other 57.1 (32) 1.7 (0.9, 3.0) 2.0 (1.0, 4.0)
CD4 counts
<200 53.5 (139) 1.0 <0.01 1.0 <0.01
200–349 37.9 (88) 0.5 (0.4, 0.8) 0.5 (0.4, 0.8)
≥350 35.3 (5) 0.5 (0.2, 1.3) 0.3 (0.1, 1.0)
VL
<5,000–1,000 57.5 (64) 1.0 0.02 1.0 0.04
5,000–9,999 44.9 (134) 0.6 (0.4, 0.9) 0.5 (0.3, 1.0)
≥10,000 34.7 (34) 0.4 (0.2, 0.7) 0.6 (0.4, 0.9)
ART regimens
AZT/3TC/NVP 44.8 (98) 1.0 0.08
d4T/3TC/NVP 54.6 (78) 1.4 (0.9, 2.2)
AZT/3TC/EFV 38.5 (30) 0.8 (0.5, 1.3)
d4T/3TC/EFV 51.2 (21) 0.9 (0.5, 1.8)
Othersa 14.7(5) 0.5 (0.2, 1.2)
Duration of ART(months)
≤26 31.7 (68) 1.0 <0.01 1.0 <0.01
27–52 56.9 (123) 2.9 (1.9, 4.2) 3.0 (2.0, 4.5)
>52 53.9 (41) 2.5 (1.5, 4.3) 2.6 (1.5, 4.6)

Note: aAZT/3TC/LPV/r, TDF/3TC/LPV/r, ABC/3TC/LPV/r, and d4T/3TC/LPV/r were included.

b

OR, Odds Ratio.