Table 4. Factors associated with HIV drug resistance among the ART-failure individuals.
Factors | Resistance% (N) | Crude ORb (95% CI) | P-value | Adjusted OR(95% CI) | P-value |
Total | 45.1 (232) | ||||
Gender | |||||
Male | 43.2 (136) | 1.00 | 0.27 | ||
Female | 48.0 (96) | 1.2 (0.9, 1.8) | |||
Ethnics | |||||
Han | 42.2 (167) | 1.00 | 0.01 | 1.0 | 0.04 |
Others | 54.6 (65) | 1.7 (1.2, 2.6) | 1.6 (1.0, 2.5) | ||
Age (years) | 0.36 | ||||
<18 | 60.7 (17) | 1.00 | |||
18–44 | 45.0 (174) | 0.5 (0.2, 1.2) | |||
≥45 | 44.2 (41) | 0.5 (0.2, 1.2) | |||
Transmission route | |||||
Sexual contact | 47.1 (123) | 1.0 | 0.02 | 1.0 | <0.01 |
Drug injection | 38.9 (77) | 0.7 (0.5, 1.1) | 0.6 (0.4, 0.9) | ||
Transfusion or other | 57.1 (32) | 1.7 (0.9, 3.0) | 2.0 (1.0, 4.0) | ||
CD4 counts | |||||
<200 | 53.5 (139) | 1.0 | <0.01 | 1.0 | <0.01 |
200–349 | 37.9 (88) | 0.5 (0.4, 0.8) | 0.5 (0.4, 0.8) | ||
≥350 | 35.3 (5) | 0.5 (0.2, 1.3) | 0.3 (0.1, 1.0) | ||
VL | |||||
<5,000–1,000 | 57.5 (64) | 1.0 | 0.02 | 1.0 | 0.04 |
5,000–9,999 | 44.9 (134) | 0.6 (0.4, 0.9) | 0.5 (0.3, 1.0) | ||
≥10,000 | 34.7 (34) | 0.4 (0.2, 0.7) | 0.6 (0.4, 0.9) | ||
ART regimens | |||||
AZT/3TC/NVP | 44.8 (98) | 1.0 | 0.08 | ||
d4T/3TC/NVP | 54.6 (78) | 1.4 (0.9, 2.2) | |||
AZT/3TC/EFV | 38.5 (30) | 0.8 (0.5, 1.3) | |||
d4T/3TC/EFV | 51.2 (21) | 0.9 (0.5, 1.8) | |||
Othersa | 14.7(5) | 0.5 (0.2, 1.2) | |||
Duration of ART(months) | |||||
≤26 | 31.7 (68) | 1.0 | <0.01 | 1.0 | <0.01 |
27–52 | 56.9 (123) | 2.9 (1.9, 4.2) | 3.0 (2.0, 4.5) | ||
>52 | 53.9 (41) | 2.5 (1.5, 4.3) | 2.6 (1.5, 4.6) |
Note: aAZT/3TC/LPV/r, TDF/3TC/LPV/r, ABC/3TC/LPV/r, and d4T/3TC/LPV/r were included.
OR, Odds Ratio.