Figure 5. Sequence similarity between initial and superinfecting variants.
Boxplots of pairwise amino acid distances in each genomic region are displayed, comparing the distance between the initial and superinfecting sequences within each superinfection case (red) to the distance between sequences in simulated mixtures of randomly selected pairs of singly-infected individuals (green). A. Analysis of 454 sequences from NGS screen. B. Analysis of 454 sequences from NGS screen and Sanger sequences from 12 previously identified cases of superinfection [5], [12], [17].
