Figure 6. Global and coarse view of the communication pathways.

The global meta paths regarding Gα_GTP ^WT and Gα_GTP ^G38D in their free state (A and B panels, respectively) as well as in ternary complex with both RGS and PDEγ (C and D panels, respectively) are represented, colored violet and green, respectively. The width of each link is proportional to r, while the sphere diameter is proportional to the average r of the connecting link (see Methods for r definition). The α-helical and Ras-like domains are dark and light gray, respectively, the PDEγ binding site on Gα is aquamarine, RGS is orange and PDEγ is lemon-green. The mutation site is indicated by the red sphere.