Table 3. Network parameters.
GαGTP WT | GαGTP G38D | GαGTP-RGS-PDEWT | GαGTP-RGS-PDEG38D | |
Imina | 3.24 | 3.23 | 3.52 | 3.58 |
Hubstotb | 34 | 33 | 51 | 51 |
Nodes 1st Clsc | 228 | 192 | 291 | 285 |
Hubs 1st Clsc | 34 | 28 | 47 | 46 |
Links 1st Clsc | 304 | 265 | 396 | 394 |
Number of Pathsd | 268 | 330 | 1930 | 975 |
1st Cluster Popd | 57 | 72 | 1819 | 924 |
2nd Cluster Popd | 27 | 37 | 80 | 36 |
3rd Cluster Popd | 26 | 34 | 22 | 7 |
4th Cluster Popd | 22 | 23 | 22 | 4 |
5th Cluster Popd | 13 | 19 | 22 | / |
Max Lengthe | 7 | 9 | 16 | 11 |
Avg Lengthe | 5.4 | 5.6 | 7.7 | 6.1 |
Max Freqf | 83.6 | 82.7 | 85.2 | 82.3 |
LengthMaxFreqf | 5 | 5 | 5 | 5 |
Max Scoreg | 1.0 | 1.0 | 1.0 | 1.0 |
Min Scoreg | 0.4 | 0.6 | 0.4 | 0.5 |
Avg Scoreg | 0.9 | 0.9 | 0.4 | 1.0 |
Max SumWgth | 79.1 | 89.2 | 155.3 | 127.8 |
Min SumWgth | 26.2 | 36.1 | 32.5 | 32.7 |
Avg SumWgth | 51.1 | 54.9 | 77.1 | 62.9 |
Max AvgWgti | 11.3 | 12.1 | 12.3 | 12.5 |
Min AvgWgti | 4.3 | 5.9 | 5.4 | 5.5 |
Avg AvgWgti | 7.9 | 8.3 | 8.8 | 8.9 |
Imin values (%) employed for the four simulated systems.
Total number of hubs.
Number of nodes, hubs and links in the most populated node cluster.
Total number of paths characterized by frequency ≥30% and number of paths in the first five most populated path clusters.
Maximum and average path length excluding the two extremities.
Maximum path frequency and length of the maximum frequency path (i.e. excluding the extremities).
Maximum, minimum and average correlation score.
Maximum, minimum and average path strength obtained by summing the interaction strengths of the links constituting the path.
Maximum, minimum and average path strength obtained by summing the interaction strengths of the links constituting the path and dividing such sum by the number of links involved in the path.