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. Author manuscript; available in PMC: 2013 Aug 29.
Published in final edited form as: Growth Factors. 2012 May 11;30(4):207–219. doi: 10.3109/08977194.2012.687375

Figure 1.

Figure 1

Negative feedback regulation of JAK/STAT signaling. Cytokine binding to specific receptors activates associated Janus Kinases (JAKs) which then tyrosine phosphorylate the intracellular domain of the receptor. These newly phosphorylated tyrosine residues on the receptor recruit the STAT family of transcription factors. STATs normally reside in the cytoplasm in an inactive state however, once bound to the receptor, they are activated by JAK and then dimerise and translocate into the nucleus where they initiate transcription of cytokine-responsive genes. SOCS3 is one of the proteins whose expression is upregulated by STAT and it then feeds back into the signaling cascade thereby inhibiting signaling and allowing the cell to return to its basal state.