Fig. 1.

Effect of BAY 60–6583 on lung permeability and mean arterial pressure (MAP) in rats subjected to trauma/hemorrhagic shock (T/HS). a Trauma/sham shock (T/SS) or T/HS rats were resuscitated with Ringer’s lactate (RL) containing 0.5 mg/kg BAY 60–6583 or its vehicle. Lung permeability was evaluated using Evan’s blue dye. ***p < 0.001 vs T/SS-vehicle, ###p < 0.001 vs. T/HS-vehicle. Data shown are mean ± SEM (n = 7 to 14). b MAP of T/SS rats resuscitated with RL containing vehicle and T/HS rats resuscitated with RL containing vehicle or 0.5 mg/kg BAY 60–6583. Data shown are representative of seven experiments in each group