Table 1.
Effects of selective adenosine receptor antagonists in OVA-induced allergic lung inflammation
| Leukocyte count (×104/ml) | Totals | Macrophages | Lymphocytes | Eosinophils | Neutrophils |
|---|---|---|---|---|---|
| Control groups | |||||
| Basal | 7.2 ± 0.6 | 6.6 ± 0.4 | 0.7 ± 0.2 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| OVA (1 %) | 24.7 ± 0.8* | 17.5 ± 0.7* | 5.4 ± 0.5* | 1.8 ± 0.4* | 0.5 ± 0.1* |
| Vehicle (Tween 20) | 24.4 ± 1.2* | 16.4 ± 1.0* | 5.6 ± 0.7* | 1.9 ± 0.0* | 0.9 ± 0.3* |
| Group treated with antagonists | |||||
| ZM241385 (1.5 mg/kg, i.p.) | 23.0 ± 1.7 | 14.2 ± 0.7 | 5.6 ± 1.9 | 3.0 ± 0.3 | 0.5 ± 0.2 |
| Alloxazine (5.0 mg/kg, i.p.) | 21.3 ± 0.9 | 14.6 ± 0.8 | 5.6 ± 0.8 | 2.0 ± 0.7 | 0.5 ± 0.3 |
| MRS3777 (5.0 mg/kg, i.p.) | 22.1 ± 1.7 | 18.8 ± 1.7 | 4.2 ± 0.8 | 1.0 ± 0.1 | 0.4 ± 0.1 |
The difference between groups was determined by ANOVA followed by Newman–Keuls multiple comparison test
*P < 0.001 when compared to basal group