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SAMHD1 hydrolysis of base-modified nucleotides. R-SAMHD1 (1 μm) was incubated with the indicated purine (A) and pyrimidine (B) nucleotide substrates (1 mm) with or without 100 μm dGTP for activation. The amount of substrate remaining in the triphosphate form was quantified by HPLC. *, p = 0.0057.
