TABLE 1.

Physiological and serum biochemical effects of VSL#3 treatment in high fat diet-fed mice

Values presented here are mean ± S.E. (n = 7). **, different in comparison with LFD; ##, different in comparison with HFD.

Measures	LFD	HFD	HFD + VSL#3
Body weight gain (g)	11.2 ± 1.02	23.2 ± 0.92	9.3 ± 1.03
Organ weight (g)
Epididymal fat pad	0.25 ± 0.02	0.78 ± 0.04**	0.31 ± 0.07##
Retroperitoneal fat pad	0.12 ± 0.04	0.33 ± 0.01**	0.14 ± 0.02##
Subscapular fat pad	0.17 ± 0.03	0.21 ± 0.01	0.18 ± 0.03
Anterior subcutaneous	0.21 ± 0.03	0.33 ± 0.02**	0.23 ± 0.03##
Posterior subcutaneous	0.19 ± 0.03	0.23 ± 0.01	0.18 ± 0.02
Spleen	0.11 ± 0.05	0.10 ± 0.01	0.11 ± 0.02
Quadriceps muscle	0.22 ± 0.04	0.23 ± 0.05	0.22 ± 0.05
Liver	1.23 ± 0.09	1.64 ± 0.1**	1.21 ± 0.08##
Fasting blood glucose (mg/dl)	60 ± 9.12	91 ± 10.34**	72 ± 11.23##
Fed blood glucose (mg/dl)	126 ± 12.13	178 ± 15.12**	132 ± 10.41##
Serum insulin (pm)	521.2 ± 26.3	1016.2 ± 51.2**	500.9 ± 34.9##
Total cholesterol (mg/dl)	54.8 ± 9.2	60.2 ± 12.3	52.4 ± 11.3
Triglycerides (mg/dl)	140.9 ± 12.4	302.5 ± 31.3**	175.1 ± 27.1##
Free fatty acids (μm)	588.2 ± 34.2	1121.3 ± 102.3**	761.1 ± 73.2##
Adiponectin (μg/ml)	22.2 ± 2.1	19.1 ± 4.2	26.3 ± 2.23##
Resistin (pg/ml)	650.2 ± 24.2	982.5 ± 46.4**	622.4 ± 44.3##
IL-6 (pg/ml)	5.2 ± 1.1	10.2 ± 1.5**	6.8 ± 1.3##
MCP-1 (pg/ml)	60.3 ± 3.4	103.2 ± 6.2**	81.2 ± 6.4##
PAI-1 (pg/ml)	2532.1 ± 123.4	2723.5 ± 412.3	2445.9 ± 334.4
TNF-α (pg/ml)	67.2 ± 5.2	102.3 ± 9.3**	72.4 ± 11.2##