FIGURE 10.
The sensitivity of rat α6β4 to inhibition by PeIA, PeIA(S9A), and PeIA(S9R). Xenopus oocytes expressing α6β4 nAChRs were subjected to TEVC as described under “Experimental Procedures,” and the IC50 values for inhibition by PeIA and two analogs were determined. PeIA, PeIA(S9A), and PeIA(S9R) inhibited α6β4 with IC50 values of 262 (201–340) nm, 1.18 (0.947–1.147) μm, and 4.46 (3.30–6.02) μm, respectively. Values in parenthesis indicate the 95% confidence interval; error bars, S.E. from 4–5 oocytes for each experimental determination.