TABLE 5.

Potencies of PeIA analogs on rat α3β2 and α6β2 nAChR mutants expressed in Xenopus oocytes

nAChR	IC50 values for PeIA(N11R)	95% C.I.	IC50 values for PeIA(A7V,S9H,V10A,N11R,E14A)	95% C.I.
rα3β2	30.9 μm	22.8–42.1	35.6 μm	25.0–50.1
rα3K152E,E184D,Q195Tβ2	4.07 μm	3.05–5.44	18.2 nm	15.3–21.7
rα6/α3β2β3	46.5 nm	35.0–61.2	2.16 nm	1.98–2.35
rα6E152K/α3β2β3	1.53 μm	0.360–6.49	311 nm	215–450
rα6E152K,D184E,T195Q/α3β2β3	6.20 μm	0.234–164	5.47 μm	3.20–9.36