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Solvent structure of NeNIR channels. Two NeNIR monomers are shown in green and pink with waters shown as red spheres with the corresponding 2Fo− Fc electron density superimposed at a contour level of 1σ. A, type 2 site showing residue Met-128 and the hydrogen-bonding network involving Asp-86 and the coordinated water molecule. B, locations of substrate channel and second water channel.
