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. 2013 Jun 3;4(6):875–883. doi: 10.18632/oncotarget.1036

Figure 4. Nuclear accumulation of ESR1 prevents proteasomal degradation in RB1 kd1 cells.

Figure 4

(A) MCF7 cells were treated with leptomycin B, estradiol or a combination for indicated time. Estradiol allows the translocation of ESR1 in the nucleus and Leptomycin B prevents the nuclear export. After 3 or 6 hours of treatment, the RB1 kd1 cells express the same level of ESR1 as scrambled cells. (B) T47D cells were treated with CHX, estradiol, or a combination for 3 hours. CHX allows nuclear accumulation of ESR1. After CHX plus estradiol treatment, the RB1 kd1 cells express the same level of ESR1 as scrambled cells.