Figure 3.

Reduction in CaMKII or PKA activity in the amygdala. (A) Rats received infusions of a PKA inhibitor (myr-PKI), CaMKII inhibitor (myr-AIP) or vehicle immediately after fear conditioning and amygdala tissue was collected 4 h later (n = 8–10 per group). (B–C) Inhibiting CaMKII, but not PKA, tended to reduce the phosphorylation of CaMKII-T286 (B) without affecting total CaMKII levels (C). (D–E) Inhibiting PKA, but not CaMKII, reduced phosphorylation of GluR1-S845 (D) without affecting total GluR1 levels (E). ^*p < 0.05 from Vehicle and myr-AIP. ^#P = 0.06 from Vehicle and myr-PKI.