Figure 2.

Perforant path depression is reduced in slices from young Syn II^−/− mice. (A,B) Color-coded fPSP activity on a selected area on the APS-MEA chip representing the response of the DG granule layer from WT (A) and pre-symptomatic Syn II^−/− (B) slices to the first (left) and the last (right) perforant path extracellular stimulation in a train of 5 s at 20 Hz. (C) Mean (±s.e.m.) ratio between the mean granule layer amplitude of the first and the last response in the train for both genotypes; ^*p < 0.05, two-tailed unpaired Student's t-test.