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Schematic illustration of solute transport from the vascular system into the brain. The solute may bind with proteins or other components in blood that may reduce the amount that can enter the brain. Solute transported across the endothelium may be partitioned between the interstitial fluid and intracellular fluid in neurons and glial cells. Solute in the interstitial fluid may be bound to the ECM, reducing the amount available for uptake by cells.
