Table 1.

Ethanol (EtOH) Concentration-Dependent Expression of EtOH Metabolism-Related Genes in the Liver of HIV-1Tg Rats

	Normal (F344) rats: up-down regulation				HIV-1Tg rats: up-down regulation
Liver	8% EtOH		52% EtOH		8% EtOH		52% EtOH
Gene symbol	Fold regulation	p-Value	Fold regulation	p-Value	Fold regulation	p-Value	Fold regulation	p-Value
Adhl	2.017	0.121416	3.1279	0.003437	1.352	0.318624	1.6487	0.200644
Adh4	2.0781	0.014263	2.3951	0.000577	1.5358	0.170954	1.2677	0.485324
Cyp2e1	1.744	0.060158	1.988	0.000085	1.2488	0.306874	−1.0609	0.9217

Significance determined at p < 0.05.

Adh1, Adh4, and Cyp2e1 gene expression was measured in the liver of young adult HIV-1Tg and F344 normal rats treated with 0% EtOH (water control), 8% EtOH, or 52% EtOH in a 3-day binge regimen (total dose of 2.0 g/kg/d), using a custom-designed 48-gene PCR array. The fold change was calculated using the ΔΔCT method relative to the 0% EtOH group (n = 3 to 4 rats for each group) for each strain (F344 or HIV-1Tg).