Figure 4.

Other developmental abnormalities. (A) Cleft palate. The upper left panel shows the gross appearance of wild-type E18.5 palate. The upper right panel shows the gross appearance of the R482Q palate, with the arrow highlighting the position of the cleft palate. The scale bar is 0.5 cm. The lower panels (left, wild-type; right, R482Q) show H&E-stained sections; the scale bar is 300 µm. (B) Eyes open at birth (EOB). The upper left panel shows the gross appearance of normal eyelid fusion in wild-type E18.5 embryos. The upper right panel shows the EOB phenotype in E18.5 R482Q embryos; the scale bar is 0.5 cm. The lower panels (left, wild-type; right, R482Q) show H&E-stained sections; the scale bar is 300 µm. The arrow highlights the failure in eyelid fusion in R482Q