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. 2013 Sep 1;126(17):3948–3960. doi: 10.1242/jcs.128033

Fig. 7.

Fig. 7.

Bone marrow transplantation reverses the increased macrophage infiltration seen in Mmp12−/− mice. (A) Wild-type mice and Mmp12−/− mice were given transplants of bone marrow from Mmp12−/− mice or wild-type mice, respectively. Representative whole-mount micrographs of the central cornea of uninjured corneas (d0) and corneas injured 6 days previously (d6) demonstrate increased F4/80+ cell infiltration after Mmp12−/− bone marrow cells are transplanted into wild-type mice. (B) Quantification of corneal F4/80 levels following bone marrow transplantation before and after injury. Mean pixel levels are shown and are 5460 (WT to Mmp12−/−; n = 9) and 10634 (Mmp12−/− to WT; n = 11) for unwounded corneas, and 64028 (WT to Mmp12−/−; n = 8) and 199503 (Mmp12−/− to WT; n = 11) 6 days after injury (n = 13), *P<0.05. (C) Wild-type mice and Mmp12−/− mice were given transplants of bone marrow from wild-type or Mmp12−/− mice, respectively. Increased F4/80+ cell infiltration occurred in the injured corneas of Mmp12−/− mice. (D) Quantification of corneal F4/80 levels following bone marrow transplantation before and after injury show increased F4/80 levels in injured corneas of Mmp12−/− mice. Mean pixel levels are 15559 (WT to WT; n = 6) and 10274 (Mmp12−/− to Mmp12−/−; n = 7) for unwounded corneas, and 78531 (WT to WT; n = 7) and 99197 (Mmp12−/− to Mmp12−/−; n = 11) 6 days after injury (n = 6), *P<0.05. Scale bars: 10 µm.