Figure 4. Transcriptome analysis of XPD^TTD fibroblasts.

Panel (a). Heatmap constructed using 136 genes downregulated in preeclampsia meta-analysis demonstrating the 34 genes significantly-downregulated in XPD^TTD Fibroblasts versus XPD^TTD Fibroblasts transfected with wild-type XPD. Panel (b). GSEA of XPD^TTD Fibroblasts with respect to genes downregulated in preeclampsia. The analysis demonstrates significant correlation (q < 0.1, Enrichment Score = 0.15) between many genes downregulated in preeclampsia and in XPD^TTD Fibroblasts. Panel (c). GO analysis of gene signature of XPD^TTD Fibroblasts using network visualization and analysis tool (as described in the Methods). Size of the nodes is inversely proportional to the p-values. Groups identified using clustering algorithm; most common GO terms are listed next to the node groups. Panel (d). Transcription factor analysis of the genes downregulated in XPD^TTD fibroblasts using network visualization and analysis tool. Groups identified using clustering algorithm; most common transcription factors are listed next to the nodes. Size of the nodes is inversely proportional to the p-values.