Table 2.

Clinical and laboratory characteristics at diagnosis of newly diagnosed pPCL patients, as reported in selected larger informative series of patients

Characteristic	Index	Values in NDMM	Newly diagnosed pPCL
			Vela-Ojeda et al9	Kraj et al52	Tiedemann et al5	Pagano et al51	Garcia-Sanz et al6	Costello et al49	Colovic et al54	Noel and Kyle7	Avet-Loiseau et al13	Woodruff et al53	Dimopoulos et al8
No. of patients			24	23	41	73	26	18	30	25	40	15	27
Clinical characteristics
Age, y	Median	66-68	64	63	55	—	66	52	60	53	62	59	57
Male	%	53-59	38	43	59	59	46	61	73	60	—	47	—
Durie-Salmon stage III	%	50-60	—	85	—	—	92	—	87	—	—	87	96
ISS stage III	%	26-34	—	80	—	78	—	—	—	—	—	—	—
Extramedullary plasmacytomas	%	5-15	—	—	22	14	23	22	23	—	—	—	—
Splenomegaly	%	1	21	—	18	18	—	28*	53	44	—	53	26
Hepatomegaly	%	4	25	—	32	23	—	28*	57	52	—	73	7
Lymphadenopathy	%	1	17	—	6	4	—	0	3	12	—	40	11
Bone disease	%	79-81	—	67	35	64	48	61	60	44	59	67	—
Laboratory characteristics
PB plasmacytosis, × 109/L	Median	0.003-0.0044	3.9	—	7.2	3.7	—	7.5	4.0	7.9	9.2	1.9	—
	Range	0-2.0	1.6-19.5	—	1.5-164	0.4-49.9	—	2.1-42	1.7-105	2.1-145.8	2.0-64	0.6-76.7	—
White blood cells, × 109/L	Median	5.8	—	15	21.5	13.7	—	24	16	19.7	—	14.5	—
Hemoglobin, g/dL	Median	10.1-10.9	—	—	9.4	9.1	8.2	9	7.8	8.4	—	7.4	—
Platelets, × 109/L	Median	209-242	—	—	98	116	123	62	—	94	—	112	—
Serum creatinine, mg/dL	Median	1.2	—	—	1.9	1.7	—	1.5	—	2.6	—	—	—
	≥ 2 mg/dL, %	19-21	50	33	—	44	44	50†	43‡	—	—	53	37
Serum calcium, mg/dL	Median	9.5-9.6	—	—	10	9.8	—	10	—	10.1	—	11.3	—
	≥ 11 mg/dL, %	13-20	37	52	—	27	48	—	60	—	—	60	44§
β2-Microglobulin, mg/L	median	3.6-3.9	10.4	8.4	6.8	8.5	—	6.0	—	—	—	—	—
	≥ 6 mg/dL, %	26-27	—	—	—	—	65	50	64	—	—	—	91
Serum albumin, g/dL	median	3.6	—	3.9	—	3.7	—	—	2.8	—	—	—	—
	< 3.5 g/dL, %	40	—	33	—	46	52	—	—	—	—	—	—
Light-chain only	%	10-20	21	19	41	41	31	28	20	50	—	40	26
BM plasmacytosis	Median	40-50	90	80	78	80	—	76	80	84	—	≥ 70	—

Presenting features of patients with newly diagnosed myeloma (NDMM) are mainly derived from 3 large series of patients.^5,6,99

— indicates not available; ISS, International Staging System; and PB, peripheral blood.

^*Splenomegaly and/or hepatomegaly.

^†Creatinine ≥ 1.4 mg/dL.

^‡Creatinine ≥ 2.8 mg/dL.

^§Calcium > 11.5 mg/dL.