Table 3.
Model 1: IGF-1 | Model 2: IGFBP-3 | |||||
---|---|---|---|---|---|---|
Measure | ORadj | 95% CI | P value | ORadj | 95% CI | P value |
Biomarkera | 0.58 | 0.42–0.79 | 0.0006 | 0.57 | 0.40–0.81 | 0.0015 |
Age | 0.97 | 0.96–0.98 | <0.0001 | 0.97 | 0.96–0.98 | <0.0001 |
APACHE III scoreb | 1.02 | 1.01–1.03 | 0.0063 | 1.02 | 1.01–1.03 | 0.0006 |
Direct pulmonary injuryc | 4.05 | 2.56–6.42 | <0.0001 | 3.84 | 2.44–6.05 | <0.0001 |
Sepsisd | 0.54 | 0.33–0.87 | 0.011 | 0.53 | 0.33–0.85 | 0.0080 |
Trauma | 0.25 | 0.086–0.70 | 0.0089 | 0.25 | 0.089–0.70 | 0.0086 |
Current diabetes | 0.59 | 0.36–0.95 | 0.031 | 0.61 | 0.38–0.99 | 0.043 |
Red cell transfusion | 1.91 | 1.23–2.96 | 0.0038 | 1.88 | 1.22–2.91 | 0.0044 |
Biomarker in Model 1 is logIGF-1; biomarker in Model 2 is logIGFBP-3
APACHE III with both age and PaO2/FiO2 removed
Direct pulmonary injury includes pneumonia, pulmonary contusion, and aspiration
Sepsis syndrome without septic shock
ORadj=Adjusted odds ratio in the multivariable model; Other covariates selected out of the models include gender, BMI, cirrhosis, estrogen/progesterone status, and septic shock