Table 1.
Inflammatory cytokines in synovial fluid of OA and RA.
| RA (n=26) | OA (n=13) | p-valuea | OPN-FL | OPN-R | OPN-L | |
|---|---|---|---|---|---|---|
| FGF-2 (pg/ml) | 66.6 (51.2–124.8)b | 15.0 (8.6–37.5) | <.001 | - | 0.463 | 0.485 |
| IP-10 (μg/ml) | 19.2 (14.9–20.0) | 11.5 (8.1–12.7) | <.001 | - | 0.446 | - |
| IL-12p40 (pg/ml) | 158.0 (19.2–235.3) | 0 (0–35.6) | 0.001 | - | 0.619 | 0.54 |
| IL-6 (pg/ml) | 2375.0 (999.5–3502.5) | 253.0 (27.5–2185.0) | 0.003 | 0.676 | 0.524 | 0.437 |
| TNFa (pg/ml) | 81.6 (49.3–151.75) | 17.2 (14.4–17.2) | 0.005 | - | 0.434 | - |
| Eotaxin (pg/ml) | 165.0 (88.1–388.5) | 0 (0–147.5) | 0.02 | - | - | 0.469 |
| GM-CSF (pg/ml) | 14.0 (3.8–54.6) | 0 (0–16.4) | 0.05 | - | - | - |
| MCP-1 (pg/ml) | 174.0 (70.1–517.0) | 209.0 (50.0–393.0) | 0.697 | - | - | - |
a
Reported P values were calculated using the Wilcoxon rank test to compare the levels of cytokines measured in synovial fluid samples derived from RA as compared to OA.
b
Median (interquartile range; 25%–75%)
Last three columns represent the correlations between OPN-FL, OPN-R and OPN-L and inflammatory cytokines in synovial fluids derived from both patients with RA and OA. The correlations between the levels of cytokines and different forms of OPN were analyzed using the data from all synovial samples and the Spearman’s rank correlation test. Spearman’s rho values from significant correlations with p < 0.01 are shown while dashes indicate that the correlation was not significant.