Fig. 3.

Paclitaxel and anthrax toxin have additive but not synergistic anti-tumor activities. Average tumor sizes (a) and body weights (b) of mice receiving vehicle (circles), paclitaxel only (squares), PA-U2/LF only (upward triangles), or the combination (downward triangles) for the duration of the study. B16-BL6 tumors were implanted in the right flank of C57BL6 mice. The mice were treated with 50 mg/kg paclitaxel or vehicle on day 5. Half of each of these groups then received 30 μg PA-U2 and 10 μg LF or vehicle on days 6, 9, and 12. The final group sizes were 10 mice per treatment. Measurements were taken before each injection and at day 14. Data are presented as mean tumor volume and error bars are standard error