Figure 2.
GLUT2 is present in the portal area but not necessary for glucose sensing. A: relative mRNA expression of GLUT2 in the portal area and liver of rats (n=3); data are expressed as means±SEM. B: protein expression of GLUT2 and glucose-6-phosphatase (catalytic unit, G6PC) in the portal area, liver and ileum of mice (representative image; three different animals are represented for portal vein). C: daily food intake of wild-type (n=8, white circles) and GLUT2-null mice (n=6, black circles) fed successively on a standard chow diet (SED, day 1–6) then on a protein-enriched diet (PED, starting day 7); for each animal data are expressed in percentage of its mean daily food intake during the 6 days under SED (reference), and represented as means±SEM for each group; *P<0.05 and **P<0.01 compared to this reference.