Fig. 3.

Disrupted lung architecture in O₂/air recovered KO mice. (A) representative hematoxylin and eosin staining of lung slices from wild type (WT) or HO-1 knockout (KO) mice are shown at 20× magnification. Inset: higher magnification (40×). Shown in (B) radial alveolar counts, in (C) average of %PCNA positive cells over DAPI counted per 10 high powered fields, (D) number of TUNEL positive cells/hpf and in E, mRNA levels of OGG1 relative to the WT air. Grey bars: WT. Open bars: KO. Values are the mean±S.E. of five experiments in each group. *: p<0.05 vs air with the same strain. †: p<0.05 vs WT O₂.