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. 2013 May 23;1(1):297–303. doi: 10.1016/j.redox.2013.04.002

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© 2013 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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Fig. 1 — Reduced and oxidized glutathione levels at P1 and P7 in lungs of mice pups born under hypoxic conditions (O14; FiO₂=14%; n=6) or under normoxic conditions (O21; FiO₂=21%; n=7). Panel A shows the reduced (GSH) to oxidized (GSSG) glutathione ratio (GSH/GSSG). Panel B represents reduced glutathione (GSH) levels. Panel C shows oxidized glutathione (GSSG) levels. Analytical determinations were performed using ultra-high performance liquid chromatography coupled to mass spectrometry (LC–MS/MS). Comparisons between groups were made using the Wilcoxon rank sum test. Statistical differences are expressed: ^⁎⁎p<0.01 vs. O21 at P1; ^⁎p<0.05 vs. O21 group at P1; and ## p<0.01 vs. O21 group at P7.