Fig. 1.

Representative raw diffusion-weighted images from a control rat are shown in (A), as well as the corresponding residual map demonstrating the accuracy of tensor fitting. Panel B shows that the STZ-induced rats had diffuse reduction of FA in bilateral striatum and motor/somatosensory cortex. Pixels with statistical significance (t > 3, voxel extent threshold = 10) are shown in color and superimposed on the population-specific FA template generated from 16 control rats and 16 STZ-induced rats. An FA threshold of 0.15 was used when generating the t map. The color bar in (A) denotes the relative amplitude of the residuals (as percentage of the signal intensity of the corresponding pixel in the raw images). The color bar in (B) denotes t scores (range 0–8).