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. 2012 Sep 14;1(1):57–65. doi: 10.1016/j.nicl.2012.09.004

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© 2012 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig. 3 — Histogram and region of interest analysis of the diffusion indices in the bilateral cortex. The group-averaged FA histograms of the bilateral cortex (from Bregma 3.00 to − 0.60 mm) are shown in the form of line graphs in A. Compared to the control group (Con), the STZ group (STZ) showed a statistically significant (*p < 0.05) increase in histogram peak height (B), but no change in histogram peak location (C). The STZ group showed significantly reduced FA only in the cortical region with FA ≥ 0.2 (D and E). Panel D shows the regions with FA ≥ 0.2 (in red color) within the cortex mask. The FA changes in the whole cortex and cortical region with FA < 0.2 (including granular layer and partly polymorphic layer) were not statistically significant (E). Panel F demonstrates that the reduction of FA in the cortical region with FA ≥ 0.2 was associated with a slightly increased radial diffusivity (D_r) and an unchanged axial diffusivity (D_a).