Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Summary of MSC-Mediated Expansion of Functional MDSCs
HGF secreted by MSCs binds to its cognate receptor, c-Met, expressed on CD14− PBLs. This leads to increased pSTAT3, a critical transcription factor in MDSC expansion. Both MSC- and HGF-expanded MDSCs are functional, expressing ARG1 and iNOS, and inhibit allogeneic lymphocyte proliferation while increasing the number of immunomodulatory Tregs.
