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. 2013 Apr-Jun;3(2):396–405. doi: 10.4103/2045-8932.114776

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Copyright: © Pulmonary Circulation

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of PSS with 4% Ficoll as a perfusate to induce HPV in the isolated perfused/ventilated mouse lung. After basal PAP was stabilized, the application of hypoxia or pretone agent or change of flow rate was performed. (A) Hypoxia alone (1% O2) did not induce vasoconstriction without a pretone agent. Increasing flow rate of perfusate (from 2 to 3 mL/min) induced the increase of the basal PAP, but not the amplitude of HPV. (B) When Ang-II (0.2 mg/100 ml) as a pretone agent was applied, a strong, transient increase of PAP was induced. After applying Ang-II to return to the basal PAP, hypoxic exposure was applied in the lung. The amplitude of HPV was slightly increased in the presence of angiotensin II but had no significant difference. Mean ± SEM is shown as a bar graph (right panel). Lungs are isolated from two to three mice.